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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-6-20
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pubmed:abstractText |
Type 1 Diabetes Mellitus is caused by auto immune destruction of insulin producing beta cells in the pancreas. Currently available treatments include transplantation of isolated islets from donor pancreas to the patient. However, this method is limited by inadequate means of immuno-suppression to prevent islet rejection and importantly, limited supply of islets for transplantation. Autologous adult stem cells are now considered for cell replacement therapy in diabetes as it has the potential to generate neo-islets which are genetically part of the treated individual. Adopting methods of islet encapsulation in immuno-isolatory devices would eliminate the need for immuno-suppressants.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e20615
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pubmed:meshHeading |
pubmed-meshheading:21687731-Adipose Tissue,
pubmed-meshheading:21687731-Adult,
pubmed-meshheading:21687731-Adult Stem Cells,
pubmed-meshheading:21687731-Animals,
pubmed-meshheading:21687731-Biological Markers,
pubmed-meshheading:21687731-Blood Glucose,
pubmed-meshheading:21687731-C-Peptide,
pubmed-meshheading:21687731-Cell Aggregation,
pubmed-meshheading:21687731-Cell Differentiation,
pubmed-meshheading:21687731-Diabetes Mellitus, Experimental,
pubmed-meshheading:21687731-Endoderm,
pubmed-meshheading:21687731-Female,
pubmed-meshheading:21687731-Humans,
pubmed-meshheading:21687731-Islets of Langerhans,
pubmed-meshheading:21687731-Male,
pubmed-meshheading:21687731-Mice,
pubmed-meshheading:21687731-Middle Aged
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pubmed:year |
2011
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pubmed:articleTitle |
Islet-like cell aggregates generated from human adipose tissue derived stem cells ameliorate experimental diabetes in mice.
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pubmed:affiliation |
Tissue Engineering and Banking Laboratory, National Centre for Cell Science, Ganeshkhind, Pune, Maharashtra, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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