|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0002073,
umls-concept:C0008109,
umls-concept:C0012854,
umls-concept:C0040648,
umls-concept:C0040845,
umls-concept:C0140278,
umls-concept:C0567416,
umls-concept:C0851285,
umls-concept:C1366536,
umls-concept:C1425420,
umls-concept:C1549879,
umls-concept:C1705627
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|
pubmed:issue |
14
|
|
pubmed:dateCreated |
2011-7-1
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|
pubmed:abstractText |
As a model compound for the transcription factor hijacking mechanism of action of DNA damaging agent that simultaneously bind to the nuclear receptor, we designed and synthesized a chimeric molecule, RA-mustard, which can bind with both retinoic acid receptor ? (RAR?) and DNA. The interaction between RA-mustard with RAR? was confirmed by binding assay using RAR?-overexpressing cell extract. RA-mustard-modified DNA diminished the RAR?-dependent luciferase expression in the RAR?-abundant cells.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1464-3405
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pubmed:author |
|
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
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pubmed:volume |
21
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
4248-51
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pubmed:meshHeading |
pubmed-meshheading:21684744-Alkylating Agents,
pubmed-meshheading:21684744-Animals,
pubmed-meshheading:21684744-COS Cells,
pubmed-meshheading:21684744-Cercopithecus aethiops,
pubmed-meshheading:21684744-Chlorambucil,
pubmed-meshheading:21684744-Computer Simulation,
pubmed-meshheading:21684744-DNA,
pubmed-meshheading:21684744-Receptors, Retinoic Acid,
pubmed-meshheading:21684744-Transcription Factors,
pubmed-meshheading:21684744-Tretinoin
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|
pubmed:year |
2011
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|
pubmed:articleTitle |
A transcription factor hijacking to regulate RAR? by using a chimeric molecule of retinoic acid and a DNA alkylator.
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|
pubmed:affiliation |
College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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