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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-7-22
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pubmed:abstractText |
Flecainide prevents arrhythmias in catecholaminergic polymorphic ventricular tachycardia, but the antiarrhythmic mechanism remains unresolved. It is possible for flecainide to directly affect the cardiac ryanodine receptor (RyR2); however, an extracellular site of action is suggested because of the hydrophilic nature of flecainide.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
291-5
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pubmed:dateRevised |
2011-10-12
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pubmed:meshHeading |
pubmed-meshheading:21680895-Animals,
pubmed-meshheading:21680895-Anti-Arrhythmia Agents,
pubmed-meshheading:21680895-Calcium Signaling,
pubmed-meshheading:21680895-Disease Models, Animal,
pubmed-meshheading:21680895-Extracellular Space,
pubmed-meshheading:21680895-Flecainide,
pubmed-meshheading:21680895-Gene Knock-In Techniques,
pubmed-meshheading:21680895-Isoproterenol,
pubmed-meshheading:21680895-Mice,
pubmed-meshheading:21680895-Mice, Mutant Strains,
pubmed-meshheading:21680895-Myocytes, Cardiac,
pubmed-meshheading:21680895-Patch-Clamp Techniques,
pubmed-meshheading:21680895-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:21680895-Sarcoplasmic Reticulum,
pubmed-meshheading:21680895-Sodium Channels,
pubmed-meshheading:21680895-Sympathomimetics,
pubmed-meshheading:21680895-Tachycardia, Ventricular
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pubmed:year |
2011
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pubmed:articleTitle |
Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity.
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pubmed:affiliation |
Cardiovascular Genetics Program, Leon H. Charney Division of Cardiology, New York University School of Medicine, 522 First Ave, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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