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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-7-4
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pubmed:abstractText |
PET of gene expression in the brain may greatly facilitate neuroscience research and potential clinical implementation of gene or cell therapy of central nervous system diseases. To date, no adequate PET reporter system is available for the central nervous system because available tracers either do not cross the intact blood-brain barrier or have high background signals. Here we report the first, to our knowledge, PET reporter system for imaging gene expression in the intact brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1535-5667
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pubmed:author |
pubmed-author:BaekelandtVeerleV,
pubmed-author:BormansGuyG,
pubmed-author:BosierBarbaraB,
pubmed-author:DebyserZegerZ,
pubmed-author:DerooseChristophe MCM,
pubmed-author:GijsbersRikR,
pubmed-author:HerveT YTY,
pubmed-author:IbrahimiAbdelilahA,
pubmed-author:JanssenPeterP,
pubmed-author:LambertDidier MDM,
pubmed-author:ToelenJaanJ,
pubmed-author:Van LaereKoenK,
pubmed-author:Van der PerrenAnkeA,
pubmed-author:VandeputteCarolineC,
pubmed-author:VerbruggenAlfonsA
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1102-9
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pubmed:meshHeading |
pubmed-meshheading:21680683-Animals,
pubmed-meshheading:21680683-Brain,
pubmed-meshheading:21680683-Carbon Radioisotopes,
pubmed-meshheading:21680683-Dependovirus,
pubmed-meshheading:21680683-Genes, Reporter,
pubmed-meshheading:21680683-Genetic Engineering,
pubmed-meshheading:21680683-Genetic Vectors,
pubmed-meshheading:21680683-HEK293 Cells,
pubmed-meshheading:21680683-Humans,
pubmed-meshheading:21680683-Indoles,
pubmed-meshheading:21680683-Male,
pubmed-meshheading:21680683-Mice,
pubmed-meshheading:21680683-Morpholines,
pubmed-meshheading:21680683-Positron-Emission Tomography,
pubmed-meshheading:21680683-Radiochemistry,
pubmed-meshheading:21680683-Rats,
pubmed-meshheading:21680683-Receptor, Cannabinoid, CB2,
pubmed-meshheading:21680683-Reproducibility of Results,
pubmed-meshheading:21680683-Species Specificity
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pubmed:year |
2011
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pubmed:articleTitle |
A PET brain reporter gene system based on type 2 cannabinoid receptors.
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pubmed:affiliation |
Division of Nuclear Medicine, University Hospital and K.U. Leuven, Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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