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pubmed:abstractText |
Cell-based therapy shows promise in treating peripheral arterial disease (PAD); however, the optimal cell type and long-term efficacy are unknown. In this study, we identified a novel subpopulation of adult progenitor cells positive for CD34 and M-cadherin (CD34?/M-cad? BMCs) in mouse and human bone marrow. We also examined the long-lasting therapeutic efficacy of mouse CD34?/M-cad? BMCs in restoring blood flow and promoting vascularization in an atherosclerotic mouse model of PAD.
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