| pubmed-article:21676616 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21676616 | lifeskim:mentions | umls-concept:C0268563 | lld:lifeskim |
| pubmed-article:21676616 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:21676616 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:21676616 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:21676616 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:21676616 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:21676616 | pubmed:dateCreated | 2011-7-1 | lld:pubmed |
| pubmed-article:21676616 | pubmed:abstractText | The bridged monobactam ?-lactamase inhibitor MK-8712 (1) effectively inhibits class C ?-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were prepared and evaluated for combination with imipenem to overcome class C ?-lactamase mediated resistance. Although some analogs were more potent inhibitors of AmpC, none exhibited better synergy with imipenem than 1. | lld:pubmed |
| pubmed-article:21676616 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21676616 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21676616 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21676616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21676616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21676616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21676616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21676616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21676616 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21676616 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21676616 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:LuJunJ | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:BlizzardTimot... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:HammondMilton... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:ScapinGiovann... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:WuJaneJ | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:KimSeongkonS | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:YoungKatherin... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:SharmaNandini... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:ParkYoung-Wha... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:ChenHelenH | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:PainterRonald... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:WisniewskiDou... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:RaghoobarSusa... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:HairstonNiche... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:FitzgeraldPau... | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:HermesJeffJ | lld:pubmed |
| pubmed-article:21676616 | pubmed:author | pubmed-author:OgawaAimie... | lld:pubmed |
| pubmed-article:21676616 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21676616 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21676616 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21676616 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:21676616 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21676616 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21676616 | pubmed:pagination | 4267-70 | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:meshHeading | pubmed-meshheading:21676616... | lld:pubmed |
| pubmed-article:21676616 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21676616 | pubmed:articleTitle | Side chain SAR of bicyclic ?-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712. | lld:pubmed |
| pubmed-article:21676616 | pubmed:affiliation | Departments of Medicinal Chemistry, Merck Research Labs, Rahway, NJ 07065, USA. helen_chen@merck.com | lld:pubmed |
| pubmed-article:21676616 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21676616 | lld:chembl |
