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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2011-7-1
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pubmed:abstractText |
The bridged monobactam ?-lactamase inhibitor MK-8712 (1) effectively inhibits class C ?-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were prepared and evaluated for combination with imipenem to overcome class C ?-lactamase mediated resistance. Although some analogs were more potent inhibitors of AmpC, none exhibited better synergy with imipenem than 1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BlizzardTimothy ATA,
pubmed-author:ChenHelenH,
pubmed-author:FitzgeraldPaulaP,
pubmed-author:HairstonNichelleN,
pubmed-author:HammondMilton LML,
pubmed-author:HermesJeffJ,
pubmed-author:KimSeongkonS,
pubmed-author:LuJunJ,
pubmed-author:OgawaAimie MAM,
pubmed-author:PainterRonald ERE,
pubmed-author:ParkYoung-WhanYW,
pubmed-author:RaghoobarSusanS,
pubmed-author:ScapinGiovannaG,
pubmed-author:SharmaNandiniN,
pubmed-author:WisniewskiDougD,
pubmed-author:WuJaneJ,
pubmed-author:YoungKatherineK
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4267-70
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pubmed:meshHeading |
pubmed-meshheading:21676616-Anti-Bacterial Agents,
pubmed-meshheading:21676616-Binding Sites,
pubmed-meshheading:21676616-Computer Simulation,
pubmed-meshheading:21676616-Enzyme Inhibitors,
pubmed-meshheading:21676616-Imipenem,
pubmed-meshheading:21676616-Microbial Sensitivity Tests,
pubmed-meshheading:21676616-Monobactams,
pubmed-meshheading:21676616-Protein Structure, Tertiary,
pubmed-meshheading:21676616-Structure-Activity Relationship,
pubmed-meshheading:21676616-beta-Lactamases
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pubmed:year |
2011
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pubmed:articleTitle |
Side chain SAR of bicyclic ?-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712.
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pubmed:affiliation |
Departments of Medicinal Chemistry, Merck Research Labs, Rahway, NJ 07065, USA. helen_chen@merck.com
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pubmed:publicationType |
Journal Article
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