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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1990-9-25
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pubmed:abstractText |
After a rapid increase in infusion rate of adrenaline to elevate the initial heart rate by more than 15%, a continuous infusion was sustained in order to maintain elevated adrenaline plasma levels. At the end of the first phase of the experiment, the thrombocyte alpha 2-adrenoceptor number (determined by radioligand binding) was significantly lowered. After the second part of the experiment, a further significant decrease in the density of binding sites was observed, while elevated adrenaline plasma levels were kept constant. The decrease in the number of binding sites was accompanied by a slight increase in affinity of the radioligand. Serum potassium concentration significantly decreased during the experiment, while other serum electrolytes showed no significant alterations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0031-7012
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2167486-Adult,
pubmed-meshheading:2167486-Binding Sites,
pubmed-meshheading:2167486-Blood Platelets,
pubmed-meshheading:2167486-Blood Pressure,
pubmed-meshheading:2167486-Catecholamines,
pubmed-meshheading:2167486-Cell Membrane,
pubmed-meshheading:2167486-Epinephrine,
pubmed-meshheading:2167486-Heart Rate,
pubmed-meshheading:2167486-Humans,
pubmed-meshheading:2167486-Infusions, Intravenous,
pubmed-meshheading:2167486-Male,
pubmed-meshheading:2167486-Platelet Aggregation,
pubmed-meshheading:2167486-Potassium,
pubmed-meshheading:2167486-Receptors, Adrenergic, alpha,
pubmed-meshheading:2167486-Yohimbine
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pubmed:year |
1990
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pubmed:articleTitle |
Time course of alpha 2-adrenoceptor desensitization induced by adrenaline infusion in man.
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pubmed:affiliation |
Center of Internal Medicine, Justus Liebig University, Giessen, FRG.
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pubmed:publicationType |
Journal Article
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