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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-7-27
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pubmed:abstractText |
Psoriasis is a common chronic autoimmune condition of the skin characterized by hyperplasia of epidermal keratinocytes associated with pro-inflammatory cytokines. IL-33 is a new member of the IL-1 superfamily that signals through the ST2 receptor and was originally defined as an inducer of T helper 2 (Th2) cytokines. Recently, broader immune activatory potential has been defined for IL-33 particularly via mast cell activation and neutrophil migration. Here, we show that ST2(-/-) mice exhibit reduced cutaneous inflammatory responses compared with WT mice in a phorbol ester-induced model of skin inflammation. Furthermore, injections of IL-33 into the ears of mice induce an inflammatory skin lesion. This inflammatory response was partially dependent on mast cells as mast cell-deficient mice (Kit(W-sh/W-sh) ) showed delayed responses to IL-33. IL-33 also recruited neutrophils to the ear, an effect mediated in part by increased production of the chemokine KC (CXCL1). Finally, we show that IL-33 expression is up-regulated in the epidermis of clinical psoriatic lesions, compared with healthy skin. These results therefore demonstrate that IL-33 may play a role in psoriasis-like plaque inflammation. IL-33 targeting may provide a new treatment strategy for psoriasis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/IL33 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Il1rl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1521-4141
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2229-37
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pubmed:meshHeading |
pubmed-meshheading:21674479-Animals,
pubmed-meshheading:21674479-Chemokine CXCL1,
pubmed-meshheading:21674479-Dermatitis,
pubmed-meshheading:21674479-Flow Cytometry,
pubmed-meshheading:21674479-Humans,
pubmed-meshheading:21674479-Interleukins,
pubmed-meshheading:21674479-Male,
pubmed-meshheading:21674479-Mast Cells,
pubmed-meshheading:21674479-Mice,
pubmed-meshheading:21674479-Mice, Inbred BALB C,
pubmed-meshheading:21674479-Mice, Inbred C57BL,
pubmed-meshheading:21674479-Mice, Knockout,
pubmed-meshheading:21674479-Neutrophil Activation,
pubmed-meshheading:21674479-Neutrophil Infiltration,
pubmed-meshheading:21674479-Neutrophils,
pubmed-meshheading:21674479-Psoriasis,
pubmed-meshheading:21674479-Receptors, Interleukin,
pubmed-meshheading:21674479-Skin,
pubmed-meshheading:21674479-Tetradecanoylphorbol Acetate
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pubmed:year |
2011
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pubmed:articleTitle |
IL-33 induces skin inflammation with mast cell and neutrophil activation.
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pubmed:affiliation |
Glasgow Biomedical Research Centre, University of Glasgow, UK. axel.hueber@uk-erlangen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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