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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-6-15
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pubmed:abstractText |
Immune challenge by bacterial lipopolysaccharide (LPS) causes short-term behavioral changes indicative of depression. The present study sought to explore whether LPS is able to induce long-term changes in depression-related behavior and whether such an effect depends on mouse strain and social context. LPS (0.83 mg/kg) or vehicle was administered intraperitoneally to female CD1 and C57BL/6 mice that were housed singly or in groups of 4. Depression-like behavior was assessed with the forced swim test (FST) 1 and 28 days post-treatment. Group-housed CD1 mice exhibited depression-like behavior 1 day post-LPS, an effect that leveled off during the subsequent 28 days, while the behavior of singly housed CD1 mice was little affected. In contrast, singly housed C57BL/6 mice responded to LPS with an increase in depression-like behavior that was maintained for 4 weeks post-treatment and confirmed by the sucrose preference test. Group-housed C57BL/6 mice likewise displayed an increased depression-like behavior 4 weeks post-treatment. The behavioral changes induced by LPS in C57BL/6 mice were associated with a particularly pronounced rise of interleukin-6 in blood plasma within 1 day post-treatment and with changes in the dynamics of the corticosterone response to the FST. The current data demonstrate that immune challenge with LPS is able to induce prolonged depression-like behavior, an effect that depends on genetic background (strain). The discovery of an experimental model of long-term depression-like behavior after acute immune challenge is of relevance to the analysis of the epigenetic and pathophysiologic mechanisms of immune system-related affective disorders.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21673960-11189026,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21673960-9617578
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e20719
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pubmed:meshHeading |
pubmed-meshheading:21673960-Animals,
pubmed-meshheading:21673960-Behavior, Animal,
pubmed-meshheading:21673960-Body Weight,
pubmed-meshheading:21673960-Corticosterone,
pubmed-meshheading:21673960-Depression,
pubmed-meshheading:21673960-Female,
pubmed-meshheading:21673960-Food Preferences,
pubmed-meshheading:21673960-Housing, Animal,
pubmed-meshheading:21673960-Hypothalamo-Hypophyseal System,
pubmed-meshheading:21673960-Interleukin-6,
pubmed-meshheading:21673960-Lipopolysaccharides,
pubmed-meshheading:21673960-Mice,
pubmed-meshheading:21673960-Social Environment,
pubmed-meshheading:21673960-Species Specificity,
pubmed-meshheading:21673960-Sucrose,
pubmed-meshheading:21673960-Time Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
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pubmed:affiliation |
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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