Linked Life Data

2167312

Source:http://linkedlifedata.com/resource/pubmed/id/2167312

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pubmed-article:2167312pubmed:abstractTextUDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1-phosphate transferase (GPT) catalyzes the initial reaction required for synthesis of dolichol-P-P-oligosaccharides. We report here on the sequence and expression of a full-length cDNA clone encoding hamster GPT. The cDNA predicts a protein of 408 amino acid residues including 10 hydrophobic segments. Several portions of the hamster GPT sequence constituting one-third of the protein have 60% or greater identity with yeast GPT, and one-half of the conserved sequence falls within the hydrophobic segments. In addition, hamster GPT has two copies of a putative dolichol recognition sequence recently identified in three yeast enzymes that interact with dolichol. The protein lacks KDEL or DEKKMP-type carboxyl-terminal ER sorting sequences. When expressed in COS-1 cells, the cDNA causes a 5-7-fold increase of GPT activity in membrane fractions. The activity was completely inhibitable by tunicamycin, and the primary product was shown to be GlcNAc-pyrophosphoryldolichol. This cDNA represents the first enzyme of the dolichol-oligosaccharide biosynthetic pathway to be cloned from a vertebrate source and demonstrates structural homology between the enzymes of the yeast and mammalian pathways.lld:pubmed
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pubmed-article:2167312pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:2167312pubmed:articleTitleCloning, sequence, and expression of a cDNA encoding hamster UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1-phosphate transferase.lld:pubmed
pubmed-article:2167312pubmed:affiliationDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235.lld:pubmed
pubmed-article:2167312pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2167312pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:2167312pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:2167312pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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