Linked Life Data

21672575

Source:http://linkedlifedata.com/resource/pubmed/id/21672575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-7-11
pubmed:abstractText
Nitric oxide (()NO) is a diffusible messenger that conveys information based on its concentration dynamics, which is dictated by the interplay between its synthesis, inactivation and diffusion. Here, we characterized ()NO diffusion in the rat brain in vivo. By direct sub-second measurement of ()NO, we determined the diffusion coefficient of ()NO in the rat brain cortex. The value of 2.2×10(-5)cm(2)/s obtained in vivo was only 14% lower than that obtained in agarose gel (used to evaluate ()NO free diffusion). These results reinforce the view of ()NO as a fast diffusing messenger but, noticeably, the data indicates that neither ()NO diffusion through the brain extracellular space nor homogeneous diffusion in the tissue through brain cells can account for the similarity between ()NO free diffusion coefficient and that obtained in the brain. Overall, the results support that ()NO diffusion in brain tissue is heterogeneous, pointing to the existence of a pathway that facilitates ()NO diffusion, such as cell membranes and other hydrophobic structures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1872-9754
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
90-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Evidence for a pathway that facilitates nitric oxide diffusion in the brain.
pubmed:affiliation
Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, Coimbra 3004-517, Portugal. Ricardo.Santos@uky.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't