Source:http://linkedlifedata.com/resource/pubmed/id/21672310
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2011-6-15
|
| pubmed:abstractText |
This prospective study explored the relationship between expression of AKR1B10 mRNA and various clinical parameters in non-small-cell lung cancer (NSCLC) in terms of its validation as a marker for NSCLC. Tumour tissue samples were collected from 229 patients with NSCLC. Tissue samples from adjacent non-malignant lung tissue (> 5 cm from the tumour) of 89 of these patients and samples from 20 patients with benign lung disease were used as controls. Quantitative reverse transcription- polymerase chain reaction showed significantly higher levels of AKR1B10 mRNA expression in NSCLC tumour tissue than in adjacent non-malignant lung tissue and benign lung tissue. Statistically significant factors for AKR1B10 mRNA over-expression were found to be male gender, smoking, squamous cell carcinoma and moderate or poor cell differentiation. It is concluded that AKR1B10 seems to have potential as a prognostic marker for NSCLC and warrants further investigation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1473-2300
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
78-85
|
| pubmed:meshHeading |
pubmed-meshheading:21672310-Adenocarcinoma,
pubmed-meshheading:21672310-Adolescent,
pubmed-meshheading:21672310-Adult,
pubmed-meshheading:21672310-Aged,
pubmed-meshheading:21672310-Aged, 80 and over,
pubmed-meshheading:21672310-Aldehyde Reductase,
pubmed-meshheading:21672310-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:21672310-Carcinoma, Squamous Cell,
pubmed-meshheading:21672310-Case-Control Studies,
pubmed-meshheading:21672310-Cell Differentiation,
pubmed-meshheading:21672310-Female,
pubmed-meshheading:21672310-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21672310-Humans,
pubmed-meshheading:21672310-Lung,
pubmed-meshheading:21672310-Lung Neoplasms,
pubmed-meshheading:21672310-Male,
pubmed-meshheading:21672310-Middle Aged,
pubmed-meshheading:21672310-Prognosis,
pubmed-meshheading:21672310-Prospective Studies,
pubmed-meshheading:21672310-RNA, Messenger,
pubmed-meshheading:21672310-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21672310-Risk Factors,
pubmed-meshheading:21672310-Smoking,
pubmed-meshheading:21672310-Tumor Markers, Biological,
pubmed-meshheading:21672310-Tumor Microenvironment
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
AKR1B10 is associated with smoking and smoking-related non-small-cell lung cancer.
|
| pubmed:affiliation |
Cancer Research Centre, Centre for Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|