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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-8-5
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pubmed:abstractText |
Several gene-expression signatures predict survival in diffuse large B-cell lymphoma (DLBCL), but the lack of practical methods for genome-scale analysis has limited translation to clinical practice. We built and validated a simple model using one gene expressed by tumor cells and another expressed by host immune cells, assessing added prognostic value to the clinical International Prognostic Index (IPI). LIM domain only 2 (LMO2) was validated as an independent predictor of survival and the "germinal center B cell-like" subtype. Expression of tumor necrosis factor receptor superfamily member 9 (TNFRSF9) from the DLBCL microenvironment was the best gene in bivariate combination with LMO2. Study of TNFRSF9 tissue expression in 95 patients with DLBCL showed expression limited to infiltrating T cells. A model integrating these 2 genes was independent of "cell-of-origin" classification, "stromal signatures," IPI, and added to the predictive power of the IPI. A composite score integrating these genes with IPI performed well in 3 independent cohorts of 545 DLBCL patients, as well as in a simple assay of routine formalin-fixed specimens from a new validation cohort of 147 patients with DLBCL. We conclude that the measurement of a single gene expressed by tumor cells (LMO2) and a single gene expressed by the immune microenvironment (TNFRSF9) powerfully predicts overall survival in patients with DLBCL.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD137,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LIM Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LMO2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1528-0020
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pubmed:author |
pubmed-author:AdvaniRanjana HRH,
pubmed-author:AlencarAlvaro JAJ,
pubmed-author:AlizadehAsh AAA,
pubmed-author:BrionesJavierJ,
pubmed-author:GascoyneRandy DRD,
pubmed-author:GentlesAndrew JAJ,
pubmed-author:GoldsteinMatthew JMJ,
pubmed-author:HouotRochR,
pubmed-author:KohrtHolbrook EHE,
pubmed-author:LevyRonaldR,
pubmed-author:LiuChih LongCL,
pubmed-author:LossosIzidore SIS,
pubmed-author:MyklebustJune HJH,
pubmed-author:NatkunamYasodhaY,
pubmed-author:PlevritisSylvia KSK,
pubmed-author:TibshiraniRobert JRJ,
pubmed-author:ZhaoShuchunS
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1350-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21670469-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:21670469-Adolescent,
pubmed-meshheading:21670469-Adult,
pubmed-meshheading:21670469-Aged,
pubmed-meshheading:21670469-Aged, 80 and over,
pubmed-meshheading:21670469-Antigens, CD137,
pubmed-meshheading:21670469-Child,
pubmed-meshheading:21670469-Cohort Studies,
pubmed-meshheading:21670469-DNA-Binding Proteins,
pubmed-meshheading:21670469-Gene Expression Profiling,
pubmed-meshheading:21670469-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21670469-Genes, Neoplasm,
pubmed-meshheading:21670469-Genetic Predisposition to Disease,
pubmed-meshheading:21670469-Genetic Testing,
pubmed-meshheading:21670469-Humans,
pubmed-meshheading:21670469-LIM Domain Proteins,
pubmed-meshheading:21670469-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:21670469-Metalloproteins,
pubmed-meshheading:21670469-Middle Aged,
pubmed-meshheading:21670469-Neoplasms,
pubmed-meshheading:21670469-Prognosis,
pubmed-meshheading:21670469-Proto-Oncogene Proteins,
pubmed-meshheading:21670469-Survival Analysis,
pubmed-meshheading:21670469-Tumor Markers, Biological,
pubmed-meshheading:21670469-Tumor Microenvironment,
pubmed-meshheading:21670469-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment.
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pubmed:affiliation |
Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA. arasha@stanford.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies,
Research Support, N.I.H., Extramural
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