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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1990-9-17
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pubmed:abstractText |
After preconstriction of rat aortic rings by norepinephrine (NE; 5*10(-5) M) or by high potassium (K+; 3*10(-2) M), a dose-dependent relaxation was induced by enoximone (E) in a range of 1*10(-5) M - 2*10(-4) M. The time to 50% dilatation was constant in that range, with mean values of 2.2 (NE) and 3.8 (K+) minutes. Also dibutyryl cyclic AMP (Db cAMP) in a range of 6*10(-5) M - 2*10(-3) M produced a dose-dependent relaxation. Comparison of the concentrations of E and Db cAMP producing equal extent of vasorelaxation demonstrated that inhibition of phosphodiesterase with E proved to be more effective than adding Db cAMP in equimolar dose.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0034-5164
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
291-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2166964-Animals,
pubmed-meshheading:2166964-Aorta, Thoracic,
pubmed-meshheading:2166964-Bucladesine,
pubmed-meshheading:2166964-Dose-Response Relationship, Drug,
pubmed-meshheading:2166964-Enoximone,
pubmed-meshheading:2166964-Imidazoles,
pubmed-meshheading:2166964-Male,
pubmed-meshheading:2166964-Norepinephrine,
pubmed-meshheading:2166964-Phosphodiesterase Inhibitors,
pubmed-meshheading:2166964-Potassium,
pubmed-meshheading:2166964-Rats,
pubmed-meshheading:2166964-Rats, Inbred BN,
pubmed-meshheading:2166964-Vasodilation
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pubmed:year |
1990
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pubmed:articleTitle |
A comparison of the vasorelaxant effects of enoximone and dibutyryl cyclic AMP measured in rat aortic rings.
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pubmed:affiliation |
Department of Internal Medicine, University Hospital Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
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