21669574

Source:http://linkedlifedata.com/resource/pubmed/id/21669574

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007600, umls-concept:C0019163, umls-concept:C0042774, umls-concept:C0220825, umls-concept:C0936012
pubmed:issue	3
pubmed:dateCreated	2011-6-14
pubmed:abstractText	Hepatitis B virus (HBV) is one of the major pathogens of human liver disease. Studies have shown that HBV X protein (HBx) plays an important role in promoting viral gene expression and replication. In this study we performed a global proteomic profiling to identify the downstream functional proteins of HBx, thereby detecting the mechanisms of action of HBx on virion replication.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101151457
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral, http://linkedlifedata.com/resource/pubmed/chemical/HSP70 Heat-Shock Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Surface Antigens, http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B e Antigens, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/hepatitis B virus X protein
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	1499-3872
pubmed:author	pubmed-author:ChengJunJ, pubmed-author:SuRongR, pubmed-author:WangJin-JinJJ, pubmed-author:WeiXu-YongXY, pubmed-author:XieHai-YangHY, pubmed-author:XingChun-YangCY, pubmed-author:ZhengShu-SenSS, pubmed-author:ZhouLinL
pubmed:issnType	Print
pubmed:volume	10
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	295-302
pubmed:meshHeading	pubmed-meshheading:21669574-Analysis of Variance, pubmed-meshheading:21669574-Blotting, Western, pubmed-meshheading:21669574-Culture Media, pubmed-meshheading:21669574-DNA, Viral, pubmed-meshheading:21669574-Electrophoresis, Gel, Two-Dimensional, pubmed-meshheading:21669574-Gene Expression Regulation, Viral, pubmed-meshheading:21669574-HSP70 Heat-Shock Proteins, pubmed-meshheading:21669574-Hep G2 Cells, pubmed-meshheading:21669574-Hepatitis B Surface Antigens, pubmed-meshheading:21669574-Hepatitis B e Antigens, pubmed-meshheading:21669574-Hepatitis B virus, pubmed-meshheading:21669574-Hepatocytes, pubmed-meshheading:21669574-Humans, pubmed-meshheading:21669574-Immunoenzyme Techniques, pubmed-meshheading:21669574-Polymerase Chain Reaction, pubmed-meshheading:21669574-Proteomics, pubmed-meshheading:21669574-RNA Interference, pubmed-meshheading:21669574-Reproducibility of Results, pubmed-meshheading:21669574-Spectrometry, Mass, Matrix-Assisted Laser..., pubmed-meshheading:21669574-Trans-Activators, pubmed-meshheading:21669574-Transfection, pubmed-meshheading:21669574-Virus Replication
pubmed:year	2011
pubmed:articleTitle	Evaluation of hepatitis B viral replication and proteomic analysis of HepG2.2.15 cell line after knockdown of HBx.
pubmed:affiliation	Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, and Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't