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pubmed-article:2166528pubmed:abstractTextSeveral N-(2-methyl or 1,2-dimethylindol-3-ylglyoxylyl)amino acid derivatives were synthesized and tested for their affinity for the benzodiazepine receptor in bovine cortical membranes. The 2-methyl derivatives showed a lower affinity than the unmethylated analogues, and the 1,2-dimethyl derivatives practically lacked any affinity for the benzodiazepine receptor. The importance of the indole N-H group is therefore evidenced for an optimal interaction of these ligands with receptor site.lld:pubmed
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pubmed-article:2166528pubmed:articleTitleSpecific inhibition of benzodiazepine receptor binding by some N-(2-methyl or 1,2-dimethylindol-3-ylglyoxylyl)amino acid derivatives.lld:pubmed
pubmed-article:2166528pubmed:affiliationIstituto di Chimica Farmaceutica dell'Università di Pisa, Italy.lld:pubmed
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