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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1990-9-17
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pubmed:abstractText |
Several N-(2-methyl or 1,2-dimethylindol-3-ylglyoxylyl)amino acid derivatives were synthesized and tested for their affinity for the benzodiazepine receptor in bovine cortical membranes. The 2-methyl derivatives showed a lower affinity than the unmethylated analogues, and the 1,2-dimethyl derivatives practically lacked any affinity for the benzodiazepine receptor. The importance of the indole N-H group is therefore evidenced for an optimal interaction of these ligands with receptor site.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-827X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
341-51
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2166528-Amino Acids,
pubmed-meshheading:2166528-Animals,
pubmed-meshheading:2166528-Binding, Competitive,
pubmed-meshheading:2166528-Cattle,
pubmed-meshheading:2166528-Cerebral Cortex,
pubmed-meshheading:2166528-Chemical Phenomena,
pubmed-meshheading:2166528-Chemistry,
pubmed-meshheading:2166528-Flunitrazepam,
pubmed-meshheading:2166528-Glyoxylates,
pubmed-meshheading:2166528-Indoles,
pubmed-meshheading:2166528-Magnetic Resonance Spectroscopy,
pubmed-meshheading:2166528-Membranes,
pubmed-meshheading:2166528-Receptors, GABA-A,
pubmed-meshheading:2166528-Spectrophotometry, Infrared
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pubmed:year |
1990
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pubmed:articleTitle |
Specific inhibition of benzodiazepine receptor binding by some N-(2-methyl or 1,2-dimethylindol-3-ylglyoxylyl)amino acid derivatives.
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pubmed:affiliation |
Istituto di Chimica Farmaceutica dell'Università di Pisa, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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