Source:http://linkedlifedata.com/resource/pubmed/id/21664042
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2011-7-4
|
| pubmed:abstractText |
miRNAs play important roles in the regulation of cell proliferation, differentiation and apoptosis. The deregulation of miRNAs expression contributes to tumorigenesis by modulating oncogenic and tumor suppressor signaling pathways. Oncogenic transcription factor Myc can control expression of a large set of microRNAs (miRNAs). Previous studies have shown that the expression of miR-17-92 cluster, a polycistron encoding six microRNAs (miRNA), has close relationship with the expression of Myc. In current study, silencing Myc in multiple myeloma (MM)cells induced cell death and growth inhibition, and downregulated expression of miR-17-92 cluster. Overexpression of miR-17 or miR-18 could partly abrogated Myc-knockdown-induced MM cell apoptosis. One of the mechanism of Myc inhibiting MM cell apoptosis is through Myc activates miR-17-92 cluster and subsequently down-modulates proapoptotic protein Bim. Although miR-17-92 cluster are located at 13q31.3, the expression of miR-18, miR-19 and miR-20 (especially miR-19) in patients with del(13q14) was higher than those without del(13q14). Patients with miR-17, miR-20 and miR-92 high-expression had shorter PFS compared to those with miR-17, miR-20 and miR-92 low-expression. These results suggest the Myc-inducible miR-17-92 cluster miRNAs contribute to tumorigenesis and poor prognosis in multiple myeloma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1872-7980
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
309
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
62-70
|
| pubmed:meshHeading |
pubmed-meshheading:21664042-Adult,
pubmed-meshheading:21664042-Aged,
pubmed-meshheading:21664042-Apoptosis,
pubmed-meshheading:21664042-Cell Line,
pubmed-meshheading:21664042-Cell Proliferation,
pubmed-meshheading:21664042-Chromosomes, Human, Pair 13,
pubmed-meshheading:21664042-Down-Regulation,
pubmed-meshheading:21664042-Female,
pubmed-meshheading:21664042-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21664042-Gene Silencing,
pubmed-meshheading:21664042-Humans,
pubmed-meshheading:21664042-Male,
pubmed-meshheading:21664042-MicroRNAs,
pubmed-meshheading:21664042-Middle Aged,
pubmed-meshheading:21664042-Multigene Family,
pubmed-meshheading:21664042-Multiple Myeloma,
pubmed-meshheading:21664042-Prognosis,
pubmed-meshheading:21664042-Proto-Oncogene Proteins c-myc
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma.
|
| pubmed:affiliation |
Department of Hematology, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, China. Chenljb@126.com
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|