Linked Life Data

21659775

Source:http://linkedlifedata.com/resource/pubmed/id/21659775

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-6-10
pubmed:abstractText
Chronic kidney disease is a leading cause of mortality and morbidity in western countries which affects about 11% of the adult population. With the increasing rate of chronic kidney disease and limited alternatives for its treatment, potential regenerative approaches for kidney damage are urgently needed, but are limited by the complexity of this organ. Bone marrow-derived stem cells as well as mesenchymal stem cells were envisioned for the development of this type of treatment. However, most studies suggested that these cells cannot differentiate into renal epithelial cells, and concluded that their beneficial effects are probably related to secretion of growth factors. In addition, a long-term partial maldifferentiation of injected mesenchymal stem cells into adipocytes accompanied by glomerular sclerosis was reported. The incapacity of bone marrow-derived stem cells to differentiate into renal cells suggested that turnover of resident renal epithelial cells may be related to the existence of potential stem/progenitor cells within the adult human kidney. Consistently, renal progenitors with the potential to differentiate into podocytes as well as tubular cells were recently identified at the urinary pole of the Bowman's capsule in adult kidneys. The discovery of renal progenitors that encourage regeneration and promote functional repair of glomerular injury demonstrates that prevention and treatment of glomerulosclerosis may be possible. In addition, converging evidence suggests that the outcome of glomerular disorders depends on a balance between injury and regeneration provided by renal progenitors. In summary, understanding how self-renewal and fate decision of renal progenitors may be perturbed or modulated will be of crucial importance to obtain novel pharmacological tools for prevention and treatment of diabetic nephropathy, as well as other causes of glomerulosclerosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1662-2782
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
228-36
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Kidney regeneration: any prospects?
pubmed:affiliation
Excellence Centre for Research, Transfer and High Education for the Development of de novo Therapies, and Meyer Children's Hospital, Nephrology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy. p.romagnani@dfc.unifi.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't