Linked Life Data

21657202

Source:http://linkedlifedata.com/resource/pubmed/id/21657202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2011-7-7
pubmed:abstractText
A series of 5-substituted 2'-deoxyuridine monophosphate analogues has been synthesized and evaluated as potential inhibitors of mycobacterial ThyX, a novel flavin-dependent thymidylate synthase in Mycobacterium tuberculosis. A systematic SAR study led to the identification of compound 5a, displaying an IC(50) value against mycobacterial ThyX of 0.91 ?M. This derivative lacks activity against the classical mycobacterial thymidylate synthase ThyA (IC(50) > 50 ?M) and represents the first example of a selective mycobacterial FDTS inhibitor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1520-4804
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4847-62
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis.
pubmed:affiliation
Katholieke Universiteit Leuven, Rega Institute for Medical Research, Leuven, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't