Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-6-9
pubmed:abstractText
A new coumarin, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl]oxy coumarin (1), together with three known compounds, schinilenol (2), schinindiol (3) and 7-[(E)-7'-hydroxy-3',7'-dimethylocta-2',5'-dienyloxy]-coumarin (4) were isolated from the methylene chloride fraction of Z. schinifolium by normal and reverse phase column chromatographies. Their structures were determined on the basis of physical and spectroscopic evidences. Compound 1 (IC(50) 8.10 ?M) showed potent cytotoxicity compared to auraptene (IC(50) 55.36 ?M) against Jurkat T cells. The other isolated compounds 2 and 4 exhibited weak cytotoxicities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0253-6269
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
723-6
pubmed:meshHeading
pubmed-meshheading:21656356-Antineoplastic Agents, Phytogenic, pubmed-meshheading:21656356-Cell Survival, pubmed-meshheading:21656356-Chromatography, High Pressure Liquid, pubmed-meshheading:21656356-Coumarins, pubmed-meshheading:21656356-Drug Discovery, pubmed-meshheading:21656356-Humans, pubmed-meshheading:21656356-Inhibitory Concentration 50, pubmed-meshheading:21656356-Isomerism, pubmed-meshheading:21656356-Jurkat Cells, pubmed-meshheading:21656356-Leukemia, T-Cell, pubmed-meshheading:21656356-Magnetic Resonance Spectroscopy, pubmed-meshheading:21656356-Mass Spectrometry, pubmed-meshheading:21656356-Methylene Chloride, pubmed-meshheading:21656356-Molecular Structure, pubmed-meshheading:21656356-Plant Extracts, pubmed-meshheading:21656356-Plant Leaves, pubmed-meshheading:21656356-Republic of Korea, pubmed-meshheading:21656356-Solvents, pubmed-meshheading:21656356-Spectroscopy, Fourier Transform Infrared, pubmed-meshheading:21656356-Zanthoxylum
pubmed:year
2011
pubmed:articleTitle
A new cytotoxic coumarin, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl] oxy coumarin, from the leaves of Zanthoxylum schinifolium.
pubmed:affiliation
College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't