|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2011-6-9
|
|
pubmed:abstractText |
Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0253-6269
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
34
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
703-7
|
|
pubmed:meshHeading |
pubmed-meshheading:21656353-Angiogenesis Inhibitors,
pubmed-meshheading:21656353-Animals,
pubmed-meshheading:21656353-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:21656353-Apoptosis,
pubmed-meshheading:21656353-Blood Vessels,
pubmed-meshheading:21656353-Cell Line, Tumor,
pubmed-meshheading:21656353-Cell Survival,
pubmed-meshheading:21656353-Drugs, Chinese Herbal,
pubmed-meshheading:21656353-Embryo, Nonmammalian,
pubmed-meshheading:21656353-Ethnopharmacology,
pubmed-meshheading:21656353-Glycosides,
pubmed-meshheading:21656353-Humans,
pubmed-meshheading:21656353-Iridoids,
pubmed-meshheading:21656353-Lung Neoplasms,
pubmed-meshheading:21656353-Luteolin,
pubmed-meshheading:21656353-Molecular Structure,
pubmed-meshheading:21656353-Plant Components, Aerial,
pubmed-meshheading:21656353-Sapogenins,
pubmed-meshheading:21656353-Saponins,
pubmed-meshheading:21656353-Stereoisomerism,
pubmed-meshheading:21656353-Verbascum,
pubmed-meshheading:21656353-Zebrafish
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Isolation of chemical constituents from the aerial parts of Verbascum thapsus and their antiangiogenic and antiproliferative activities.
|
|
pubmed:affiliation |
Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
