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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-6-29
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pubmed:abstractText |
D-Glucuronyl C5-epimerase (GLCE) is a key enzyme involved in the biosynthesis of heparan sulphate proteoglycans, which has an important role in cell-cell and cell-matrix interactions and signalling. Decreased GLCE expression in human breast tumours and its anti-proliferative effects in breast cancer cells suggest that it may be a candidate tumour-suppressor gene. The aim of this study was to investigate the involvement of GLCE in lung carcinogenesis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1532-1827
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-82
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pubmed:meshHeading |
pubmed-meshheading:21654676-Animals,
pubmed-meshheading:21654676-Blotting, Western,
pubmed-meshheading:21654676-Carbohydrate Epimerases,
pubmed-meshheading:21654676-Cell Proliferation,
pubmed-meshheading:21654676-Fluorescent Antibody Technique,
pubmed-meshheading:21654676-Humans,
pubmed-meshheading:21654676-Immunoenzyme Techniques,
pubmed-meshheading:21654676-Lung Neoplasms,
pubmed-meshheading:21654676-Mice,
pubmed-meshheading:21654676-Mice, SCID,
pubmed-meshheading:21654676-RNA, Messenger,
pubmed-meshheading:21654676-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21654676-Small Cell Lung Carcinoma,
pubmed-meshheading:21654676-Tumor Cells, Cultured
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pubmed:year |
2011
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pubmed:articleTitle |
D-glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo.
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pubmed:affiliation |
Institute of Molecular Biology and Biophysics SD RAMS, Timakova str 2, Novosibirsk 630117, Russia. elv_grig@yahoo.com
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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