Linked Life Data

2165438

Source:http://linkedlifedata.com/resource/pubmed/id/2165438

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1990-9-5
pubmed:abstractText
The effect of the selective kappa opiate agonist U50,488 on the firing rate of neurons of the substantia nigra pars reticulata (SNR) was investigated in a series of extracellular single unit recording experiments in rats. Intravenous administration of U50,488 produced a dose-related decrease in the spontaneous firing rate of SNR neurons, an effect that was reversed by naloxone in most cases. Iontophoretic application of the kappa agonist also inhibited the firing of SNR neurons, indicating a direct action of U50,488 in the SNR. U50,488 was particularly effective in inhibiting a local group of SNR neurons that exhibit increased firing in response to mechanical pressure. In separate experiments, it was determined that these pressure sensitive neurons (1) include nigrotectal and nigrothalamic cells, (2) are responsive to mild as well as painful levels of pressure, and (3) are not responsive to light flashes. This group of neurons may be a primary target of naturally occurring kappa selective opioids of the prodynorphinergic striatonigral pathway.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
517
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Inhibitory effects of the kappa opiate U50,488 in the substantia nigra pars reticulata.
pubmed:affiliation
Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI 02912.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't