Linked Life Data

2165401

Source:http://linkedlifedata.com/resource/pubmed/id/2165401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-8-30
pubmed:abstractText
The antimalarial activity of diethyldithiocarbamate (DDC) in vitro was potentiated by subtoxic concentrations of copper. DDC was also more potent in the presence of an intracellular source of copper, such as when parasites were grown in superoxide dismutase (SOD)-loaded erythrocytes. These data suggest that DDC forms a complex with copper, either intracellularly or extracellularly, which is toxic to malarial parasites. The exact cause of this toxicity is not known, but may be due to a membrane effect, since DDC and copper, in combination, exert a potent lytic effect on normal human erythrocytes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Antimalarial activity of diethyldithiocarbamate. Potentiation by copper.
pubmed:affiliation
City University of New York Medical School, NY 10031.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't