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rdf:type |
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lifeskim:mentions |
umls-concept:C0026809,
umls-concept:C0035820,
umls-concept:C0054594,
umls-concept:C0152254,
umls-concept:C0160390,
umls-concept:C0205216,
umls-concept:C0205217,
umls-concept:C0378126,
umls-concept:C0596570,
umls-concept:C0687725,
umls-concept:C1413555
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pubmed:issue |
6
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pubmed:dateCreated |
2011-6-7
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pubmed:abstractText |
Alcohol is a common cause of hepatic liver injury with steatosis and fibrosis. Cannabinoid receptors (CB) modulate steatosis, inflammation and fibrogenesis. To investigate the differences between CB(1) and CB(2) in the hepatic response to chronic alcohol intake, we examined CB knockout mice (CB(1)(-/-), CB(2)(-/-)).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyproline,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB2,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1478-3231
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pubmed:author |
pubmed-author:CaraErlindE,
pubmed-author:FischerHans-PeterHP,
pubmed-author:GranzowMichaelaM,
pubmed-author:HellerJörgJ,
pubmed-author:HennenbergMartinM,
pubmed-author:HussSebastianS,
pubmed-author:KleinSabineS,
pubmed-author:RaczIldikoI,
pubmed-author:SauerbruchTilmanT,
pubmed-author:SchierwagenRobertR,
pubmed-author:SiegmundSören VSV,
pubmed-author:TrebickaJonelJ,
pubmed-author:WojtallaAlexandraA,
pubmed-author:ZimmerAndreasA
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pubmed:copyrightInfo |
© 2011 John Wiley & Sons A/S.
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
860-70
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pubmed:meshHeading |
pubmed-meshheading:21645218-Animals,
pubmed-meshheading:21645218-Biological Markers,
pubmed-meshheading:21645218-Blotting, Western,
pubmed-meshheading:21645218-Cell Proliferation,
pubmed-meshheading:21645218-Disease Models, Animal,
pubmed-meshheading:21645218-Ethanol,
pubmed-meshheading:21645218-Fatty Liver, Alcoholic,
pubmed-meshheading:21645218-Female,
pubmed-meshheading:21645218-Gene Expression Regulation,
pubmed-meshheading:21645218-Hepatic Stellate Cells,
pubmed-meshheading:21645218-Hepatitis, Alcoholic,
pubmed-meshheading:21645218-Hydroxyproline,
pubmed-meshheading:21645218-Inflammation Mediators,
pubmed-meshheading:21645218-Liver,
pubmed-meshheading:21645218-Liver Cirrhosis, Alcoholic,
pubmed-meshheading:21645218-Mice,
pubmed-meshheading:21645218-Mice, Inbred C57BL,
pubmed-meshheading:21645218-Mice, Knockout,
pubmed-meshheading:21645218-RNA, Messenger,
pubmed-meshheading:21645218-Receptor, Cannabinoid, CB1,
pubmed-meshheading:21645218-Receptor, Cannabinoid, CB2,
pubmed-meshheading:21645218-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21645218-Time Factors,
pubmed-meshheading:21645218-Triglycerides
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pubmed:year |
2011
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pubmed:articleTitle |
Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts.
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pubmed:affiliation |
Department of Internal Medicine I, University of Bonn, Bonn, Germany. jonel.trebicka@ukb.uni-bonn.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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