Linked Life Data

2164230

Source:http://linkedlifedata.com/resource/pubmed/id/2164230

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-8-16
pubmed:abstractText
To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0165-1781
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
39-48
pubmed:dateRevised
2008-4-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Acute effects of ethanol on regional brain glucose metabolism and transport.
pubmed:affiliation
Medical Department, Brookhaven National Laboratory, Upton, NY 11973.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.