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pubmed:abstractText |
Scatchard plots of equilibrium saturation binding data revealed that haloperidol inhibits the binding of (+)-[3H]SKF-10,047 to sigma sites in a competitive manner. In experiments using membranes from both guinea pig and rat brain the apparent Kd of (+)-[3H]SKF-10,047 for sigma sites was significantly increased, whereas the apparent Bmax was not altered by the addition of 10 nM haloperidol.
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