Linked Life Data

2163850

Source:http://linkedlifedata.com/resource/pubmed/id/2163850

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1990-8-13
pubmed:abstractText
In the sheep cerebral vasculature 5-hydroxytryptamine (5-HT) caused a contraction of which ketanserin was found to be an effective antagonist (Basilar artery, pA2 = 9.33 +/- 0.16; middle cerebral artery, pA2 = 9.19 +/- 0.16; pial artery, pA2 = 9.47 +/- 0.12). Sumatriptan (GR 43175), a selective 5-HT1-like receptor agonist, was also found to have a small contractile effect on the sheep cerebral vasculature (Basilar artery, pD2 = 6.26 +/- 0.11; middle cerebral artery, pD2 = 6.25 +/- 0.10; pial artery, pD2 = 6.13 +/- 0.15). The contractile effect of sumatriptan was not antagonised by either ketanserin (1 microM) or MDL 72222 (1 microM). 5-HT therefore appears to cause contraction by stimulation of a mixed receptor population of 5-HT1-like and 5-HT2 receptors. In the sheep middle cerebral artery the addition of haemolysate was found to cause a contractile response and also to augment the contractile effects of both noradrenaline and 5-HT but only in the presence of a functional endothelium. However, 5-HT was never found to relax precontracted rings of the middle cerebral artery in either the presence or absence of a functional endothelium. These results indicate a basal release of EDRF in cerebral arteries that attenuates the effects of various constrictor agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
179
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Pharmacological characterisation of postjunctional 5-HT receptors in cerebral arteries from the sheep.
pubmed:affiliation
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't