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rdf:type |
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lifeskim:mentions |
umls-concept:C0005516,
umls-concept:C0021053,
umls-concept:C0036421,
umls-concept:C0039194,
umls-concept:C0041904,
umls-concept:C0085358,
umls-concept:C0162493,
umls-concept:C0332294,
umls-concept:C0442802,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C1819440,
umls-concept:C2698600
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pubmed:issue |
6
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pubmed:dateCreated |
2011-6-3
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pubmed:abstractText |
Despite the importance of interleukin-13 (IL-13) in systemic sclerosis (SSc) and other fibrotic diseases, its mechanisms of action are not understood. We have reported that excessive amounts of IL-13 are produced by peripheral blood effector CD8+ T cells from patients with diffuse cutaneous SSc (dcSSc). The aim of the present study was to establish the molecular basis of IL-13 dysregulation in the pathogenesis of SSc.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1529-0131
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 by the American College of Rheumatology.
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pubmed:issnType |
Electronic
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1738-47
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21638273-Adult,
pubmed-meshheading:21638273-Biological Markers,
pubmed-meshheading:21638273-CD8-Positive T-Lymphocytes,
pubmed-meshheading:21638273-Down-Regulation,
pubmed-meshheading:21638273-Female,
pubmed-meshheading:21638273-GATA3 Transcription Factor,
pubmed-meshheading:21638273-Humans,
pubmed-meshheading:21638273-Interferon-gamma,
pubmed-meshheading:21638273-Interleukin-13,
pubmed-meshheading:21638273-Male,
pubmed-meshheading:21638273-Middle Aged,
pubmed-meshheading:21638273-RNA, Small Interfering,
pubmed-meshheading:21638273-Scleroderma, Diffuse,
pubmed-meshheading:21638273-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production.
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pubmed:affiliation |
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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