Source:http://linkedlifedata.com/resource/pubmed/id/21636641
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2011-7-8
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| pubmed:abstractText |
Forced expression of selected transcription factors can transform somatic cells into embryonic stem cell (ESC)-like cells, termed induced pluripotent stem cells (iPSCs). There is no consensus regarding the preferred tissue from which to harvest donor cells for reprogramming into iPSCs, and some donor cell types may be more prone than others to accumulation of epigenetic imprints and somatic cell mutations. Here, we present a simple, reproducible, noninvasive method for generating human iPSCs from renal tubular cells present in urine. This procedure eliminates many problems associated with other protocols, and the resulting iPSCs display an excellent ability to differentiate. These data suggest that urine may be a preferred source for generating iPSCs.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1533-3450
|
| pubmed:author |
pubmed-author:BendaChristinaC,
pubmed-author:CaoGuokunG,
pubmed-author:ChanYau-ChiYC,
pubmed-author:DuzingerSarahS,
pubmed-author:EstebanMiguel AMA,
pubmed-author:Grillari-VoglauerReginaR,
pubmed-author:GrillariJohannesJ,
pubmed-author:GuoXiangpengX,
pubmed-author:HoJenny CyJC,
pubmed-author:HuangYinghuaY,
pubmed-author:LiXingyanX,
pubmed-author:LiYanhuaY,
pubmed-author:NgKwong-ManKM,
pubmed-author:NunnKK,
pubmed-author:PeiDuanqingD,
pubmed-author:RedlHeinzH,
pubmed-author:ShenChenC,
pubmed-author:TseHung-FatHF,
pubmed-author:WieserMatthiasM,
pubmed-author:WuJiayanJ,
pubmed-author:ZhouTingT
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| pubmed:copyrightInfo |
Copyright © 2011 by the American Society of Nephrology
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1221-8
|
| pubmed:meshHeading |
pubmed-meshheading:21636641-Aged,
pubmed-meshheading:21636641-Female,
pubmed-meshheading:21636641-Gene Transfer Techniques,
pubmed-meshheading:21636641-Humans,
pubmed-meshheading:21636641-Induced Pluripotent Stem Cells,
pubmed-meshheading:21636641-Kidney Tubules,
pubmed-meshheading:21636641-Male,
pubmed-meshheading:21636641-Urine,
pubmed-meshheading:21636641-Young Adult
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Generation of induced pluripotent stem cells from urine.
|
| pubmed:affiliation |
Stem Cell and Cancer Biology Group, Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Chinese Academy of Sciences, Guangzhou, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|