Linked Life Data

21636639

Source:http://linkedlifedata.com/resource/pubmed/id/21636639

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-7-8
pubmed:abstractText
Nephrogenesis is ongoing at the time of birth for the majority of preterm infants, but whether postnatal renal development follows a similar trajectory to normal in utero growth is unknown. Here, we examined tissue collected at autopsy from 28 kidneys from preterm neonates, whose postnatal survival ranged from 2 to 68 days, including 6 that had restricted intrauterine growth. In addition, we examined kidneys from 32 still-born gestational controls. We assessed the width of the nephrogenic zone, number of glomerular generations, cross-sectional area of the renal corpuscle, and glomerular maturity and morphology. Renal maturation accelerated after preterm birth, with an increased number of glomerular generations and a decreased width of the nephrogenic zone in the kidneys of preterm neonates. Of particular concern, compared with gestational controls, preterm kidneys had a greater percentage of morphologically abnormal glomeruli and a significantly larger cross-sectional area of the renal corpuscle, suggestive of renal hyperfiltration. These observations suggest that the preterm kidney may have fewer functional nephrons, thereby increasing vulnerability to impaired renal function in both the early postnatal period and later in life.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1533-3450
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 by the American Society of Nephrology
pubmed:issnType
Electronic
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1365-74
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Accelerated maturation and abnormal morphology in the preterm neonatal kidney.
pubmed:affiliation
Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, 3800, Australia.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't