Linked Life Data

21635552

Source:http://linkedlifedata.com/resource/pubmed/id/21635552

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-6-3
pubmed:abstractText
The purpose of this study was to evaluate the association between the expression of growth factors and the clinicopathological variables of colorectal adenocarcinoma. Immunohistochemistry and fluorescence in situ hybridization (FISH) were used to evaluate the amplification and expression of epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), VEGF-D, VEGF receptor (VEGFR)-2, VEGFR-3, transforming growth factor (TGF)-?1, and insulin-like growth factor-1 receptor (IGF-1R) in a tissue microarray of 292 colorectal adenocarcinomas. The expression of EGFR, VEGF, VEGF-D, VEGFR-2 and VEGFR-3 was detected in 5.1%, 10.0%, 6.8%, 5.2%, and 57.2%. EGFR expression was associated with angioinvasion (p < 0.05) and lymph node metastasis (p < 0.005). VEGFR-3 expression was higher in the rectum than in the colon (p < 0.05). VEGF expression correlated with VEGF-D (p < 0.05) and VEGFR-3 (p < 0.005) expression, while VEGF-D expression showed no significant association with VEGFR-2 or VEGFR-3. EGFR amplification was present in 10.6% and was not associated with EGFR protein expression. VEGFR-2 and VEGFR-3 expression levels were related to poor patient survival. Stage, perineural invasion, and lymph node metastasis were independent prognostic factors based on a Cox analysis. VEGFR-2 and VEGFR-3 expression are markers of a poor prognosis in patients with surgically resected colorectal adenocarcinoma, whereas EGFR has a minor influence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1600-0463
pubmed:author
pubmed:copyrightInfo
© 2011 The Authors. APMIS © 2011 APMIS.
pubmed:issnType
Electronic
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
449-59
pubmed:meshHeading
pubmed-meshheading:21635552-Adenocarcinoma, pubmed-meshheading:21635552-Adult, pubmed-meshheading:21635552-Aged, pubmed-meshheading:21635552-Aged, 80 and over, pubmed-meshheading:21635552-Cell Proliferation, pubmed-meshheading:21635552-Colorectal Neoplasms, pubmed-meshheading:21635552-Disease Progression, pubmed-meshheading:21635552-Female, pubmed-meshheading:21635552-Fluorescent Antibody Technique, pubmed-meshheading:21635552-Gene Expression, pubmed-meshheading:21635552-Humans, pubmed-meshheading:21635552-In Situ Hybridization, Fluorescence, pubmed-meshheading:21635552-Male, pubmed-meshheading:21635552-Microarray Analysis, pubmed-meshheading:21635552-Middle Aged, pubmed-meshheading:21635552-Prognosis, pubmed-meshheading:21635552-Receptor, Epidermal Growth Factor, pubmed-meshheading:21635552-Receptor, IGF Type 1, pubmed-meshheading:21635552-Survival Rate, pubmed-meshheading:21635552-Transforming Growth Factor beta1, pubmed-meshheading:21635552-Vascular Endothelial Growth Factor D, pubmed-meshheading:21635552-Vascular Endothelial Growth Factor Receptor-2, pubmed-meshheading:21635552-Vascular Endothelial Growth Factor Receptor-3
pubmed:year
2011
pubmed:articleTitle
Prognostic significance of epidermal growth factor receptor and vascular endothelial growth factor receptor in colorectal adenocarcinoma.
pubmed:affiliation
Department of Pathology, Inje University Sanggye Paik Hospital, Seoul, Korea. jykimpath@paik.ac.kr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't