| pubmed-article:21635228 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21635228 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:21635228 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21635228 | lifeskim:mentions | umls-concept:C0024143 | lld:lifeskim |
| pubmed-article:21635228 | lifeskim:mentions | umls-concept:C0247771 | lld:lifeskim |
| pubmed-article:21635228 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:21635228 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21635228 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:21635228 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21635228 | pubmed:dateCreated | 2011-7-5 | lld:pubmed |
| pubmed-article:21635228 | pubmed:abstractText | Studies have indicated that interleukin (IL)-10 has a pathogenic role in systemic lupus erythematosus (SLE); however, a protective effect of IL-10 in SLE was also observed. Because the exact mechanism of IL-10 signalling in the pathogenesis of SLE is unclear, this study sought to assess the expression and signalling of interleukin-10 receptor (IL-10R) in peripheral leucocytes from patients with SLE. We used flow cytometry to examine the expression of IL-10R1 on different peripheral leucocytes from 28 SLE patients, of whom 14 had lupus nephritis (LN) and 14 were healthy controls. We also examined the effects of IL-10 on phosphorylation of signal transducer and activator of transcription (STAT)-3 and STAT-1 in peripheral blood mononuclear cells (PBMCs) obtained from 13 SLE patients and seven healthy controls. Plasma cytokines were detected by flow cytometric bead array (CBA) techniques. Although IL-10R1 expression levels on each peripheral leucocyte subset from 28 SLE patients and 14 healthy controls were similar, the expression levels on CD4(+) T cells from LN patients were significantly lower than on CD4(+) T cells from controls and SLE patients without nephritis (P < 0·01). IL-10R1 expression levels on CD4(+) and CD8(+) T cells were correlated negatively with the SLE disease activity index (P < 0·01). Additionally, the phosphorylation of STAT-3 was delayed and reduced in PBMCs from LN patients and active SLE patients. Plasma IL-10 levels were significantly higher in LN patients than controls. IL-10R1 expression on CD4(+) T cells and signalling in PBMCs were down-regulated in LN patients, indicating that IL-10 and its receptor may have a special role in LN pathogenesis. | lld:pubmed |
| pubmed-article:21635228 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21635228 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21635228 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21635228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21635228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21635228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21635228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21635228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21635228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21635228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21635228 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21635228 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:21635228 | pubmed:issn | 1365-2249 | lld:pubmed |
| pubmed-article:21635228 | pubmed:author | pubmed-author:JiangYY | lld:pubmed |
| pubmed-article:21635228 | pubmed:author | pubmed-author:YangL LLL | lld:pubmed |
| pubmed-article:21635228 | pubmed:author | pubmed-author:WanW HWH | lld:pubmed |
| pubmed-article:21635228 | pubmed:author | pubmed-author:ZhangX LXL | lld:pubmed |
| pubmed-article:21635228 | pubmed:author | pubmed-author:REGG | lld:pubmed |
| pubmed-article:21635228 | pubmed:author | pubmed-author:ZhangNN | lld:pubmed |
| pubmed-article:21635228 | pubmed:author | pubmed-author:DuS YSY | lld:pubmed |
| pubmed-article:21635228 | pubmed:author | pubmed-author:MoZ CZC | lld:pubmed |
| pubmed-article:21635228 | pubmed:copyrightInfo | © 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology. | lld:pubmed |
| pubmed-article:21635228 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21635228 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:21635228 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21635228 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21635228 | pubmed:pagination | 163-71 | lld:pubmed |
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| pubmed-article:21635228 | pubmed:meshHeading | pubmed-meshheading:21635228... | lld:pubmed |
| pubmed-article:21635228 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21635228 | pubmed:articleTitle | Interleukin-10 receptor expression and signalling were down-regulated in CD4? T cells of lupus nephritis patients. | lld:pubmed |
| pubmed-article:21635228 | pubmed:affiliation | Department of Rheumatology and Immunology, Shengjing Hospital, Shenyang, China. | lld:pubmed |
| pubmed-article:21635228 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21635228 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3587 | entrezgene:pubmed | pubmed-article:21635228 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21635228 | lld:entrezgene |
