|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2011-7-12
|
|
pubmed:abstractText |
In pediatric onset of Crohn's disease (CD), corticosteroid dependency (approximately 40%) and resistance (approximately 10%) are significant clinical problems. Given the known effects of the glucocorticoid receptor (GR/NR3C1) gene in corticosteroid metabolism, we investigated whether variation in the gene was associated with corticosteroid response.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1744-6880
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
454-60
|
|
pubmed:meshHeading |
pubmed-meshheading:21633323-Adolescent,
pubmed-meshheading:21633323-Adrenal Cortex Hormones,
pubmed-meshheading:21633323-Alleles,
pubmed-meshheading:21633323-Child,
pubmed-meshheading:21633323-Crohn Disease,
pubmed-meshheading:21633323-Drug Resistance,
pubmed-meshheading:21633323-Female,
pubmed-meshheading:21633323-Genetic Association Studies,
pubmed-meshheading:21633323-Genetic Variation,
pubmed-meshheading:21633323-Genotype,
pubmed-meshheading:21633323-Haplotypes,
pubmed-meshheading:21633323-Humans,
pubmed-meshheading:21633323-Male,
pubmed-meshheading:21633323-Polymorphism, Single Nucleotide,
pubmed-meshheading:21633323-Receptors, Glucocorticoid
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Variation in the glucocorticoid receptor gene (NR3C1) may be associated with corticosteroid dependency and resistance in children with Crohn's disease.
|
|
pubmed:affiliation |
Research Centre, Sainte-Justine Hospital, Montreal, Quebec, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
