Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-6-2
pubmed:abstractText
Effects of ranolazine alone and in the presence of phenylephrine (PE) or isoproterenol (ISO) on hemodynamics, coronary blood flow and heart rate (HR) in the absence and presence of hexamethonium (a ganglionic blocker) were studied in conscious dogs. Ranolazine (0.4, 1.2, 3.6, and 6 mg/kg, intravenous) alone caused transient (<1 minute) and reversible hemodynamic changes. PE (0.3-10 ?g/kg) caused a dose-dependent increase in blood pressure and decrease in HR. ISO (0.01-0.3 ?g/kg) caused a dose-dependent decrease in blood pressure and an increase in HR. Ranolazine at high (11-13 mM), but not at moderate (4-5 mM) concentrations partially attenuated changes in mean arterial blood pressure and HR caused by either PE or ISO in normal conscious dogs. However, in dogs treated with hexamethonium (20 mg/kg) to cause autonomic blockade, ranolazine (both 4-5 and 11-13 ?M) significantly attenuated both the PE- and ISO-induced changes in mean arterial blood pressure. The results suggest that a potential antiadrenergic effect of ranolazine was masked by autonomic control mechanisms in conscious dogs but could be observed when these mechanisms were inhibited (eg, in the hexamethonium-treated dog). Ranolazine, at plasma concentrations <10 ?M and in conscious dogs with intact autonomic regulation, had minimal antiadrenergic (? and ?) effects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Acetanilides, http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Autonomic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Ganglionic Blockers, http://linkedlifedata.com/resource/pubmed/chemical/Hexamethonium, http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol, http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine, http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta, http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents, http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents, http://linkedlifedata.com/resource/pubmed/chemical/ranolazine
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1533-4023
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
639-47
pubmed:meshHeading
pubmed-meshheading:21633249-Acetanilides, pubmed-meshheading:21633249-Adrenergic Antagonists, pubmed-meshheading:21633249-Animals, pubmed-meshheading:21633249-Autonomic Agents, pubmed-meshheading:21633249-Coronary Circulation, pubmed-meshheading:21633249-Dogs, pubmed-meshheading:21633249-Dose-Response Relationship, Drug, pubmed-meshheading:21633249-Ganglionic Blockers, pubmed-meshheading:21633249-Guinea Pigs, pubmed-meshheading:21633249-Heart Rate, pubmed-meshheading:21633249-Hemodynamics, pubmed-meshheading:21633249-Hexamethonium, pubmed-meshheading:21633249-Hypertension, pubmed-meshheading:21633249-Hypotension, pubmed-meshheading:21633249-Isoproterenol, pubmed-meshheading:21633249-Kinetics, pubmed-meshheading:21633249-Phenylephrine, pubmed-meshheading:21633249-Piperazines, pubmed-meshheading:21633249-Rats, pubmed-meshheading:21633249-Receptors, Adrenergic, alpha, pubmed-meshheading:21633249-Receptors, Adrenergic, beta, pubmed-meshheading:21633249-Vasoconstrictor Agents, pubmed-meshheading:21633249-Vasodilator Agents
pubmed:year
2011
pubmed:articleTitle
Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs.
pubmed:affiliation
Department of Biology, Gilead Sciences Palo Alto, Palo Alto, CA, USA. gong.zhao@gilead.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural