Source:http://linkedlifedata.com/resource/pubmed/id/21633177
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2011-6-2
|
| pubmed:abstractText |
To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that limits healthy expansion. Proper expansion requires a highly coordinated response among many different cell types, including endothelial precursor cells, immune cells, and preadipocytes. There are therefore remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1558-8238
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
121
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2094-101
|
| pubmed:meshHeading |
pubmed-meshheading:21633177-Adaptation, Physiological,
pubmed-meshheading:21633177-Adipocytes,
pubmed-meshheading:21633177-Adipose Tissue,
pubmed-meshheading:21633177-Animals,
pubmed-meshheading:21633177-Cell Division,
pubmed-meshheading:21633177-Cell Hypoxia,
pubmed-meshheading:21633177-Cell Size,
pubmed-meshheading:21633177-Endothelial Cells,
pubmed-meshheading:21633177-Energy Metabolism,
pubmed-meshheading:21633177-Extracellular Matrix,
pubmed-meshheading:21633177-Fatty Acids,
pubmed-meshheading:21633177-Humans,
pubmed-meshheading:21633177-Inflammation,
pubmed-meshheading:21633177-Macrophages,
pubmed-meshheading:21633177-Mice,
pubmed-meshheading:21633177-Mice, Transgenic,
pubmed-meshheading:21633177-Neovascularization, Physiologic,
pubmed-meshheading:21633177-Obesity,
pubmed-meshheading:21633177-Weight Loss
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Adipose tissue remodeling and obesity.
|
| pubmed:affiliation |
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8549, USA.
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|