Linked Life Data

21632868

Source:http://linkedlifedata.com/resource/pubmed/id/21632868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-8-23
pubmed:abstractText
The excitation of the renal sympathetic nervous system plays an important role in the development of ischemic acute kidney injury (AKI) in rats. We have reported that intravenous treatment with GABA has preventive effects on ischemia/reperfusion (I/R)-induced renal dysfunction with histological damage in rats. However, detailed mechanisms of the action of GABA on the renal injury were still unknown. Therefore, in the present study, we aimed to clarify the detailed mechanisms of GABA in ischemic AKI in rats. Ischemic AKI was induced by clamping the left renal artery and vein for 45 min. Thereafter, the kidney was reperfused to produce I/R-induced injury. Intravenous or intracerebroventricular treatment with 3-[[[(3,4-dichlorophenyl)methyl]amino]propyl] diethoxymethyl) phosphinic acid (CGP52432), a GABA(B) receptor antagonist, abolished the suppressive effects of intravenously applied GABA on enhanced renal sympathetic nerve activity during ischemia, leading to the elimination of the renoprotective effects of GABA. Intracerebroventricular treatment with GABA or intravenous treatment with baclofen, a selective GABA(B) receptor agonist, prevented I/R-induced renal injury equivalent to intravenous treatment with GABA. However, intravenous treatment with bicuculline, a GABA(A) receptor antagonist, failed to affect the preventive effects of GABA on ischemic AKI. Therefore, we demonstrated the novel finding that the preventive effect of GABA on ischemic AKI through the suppression of enhanced renal sympathetic nerve activity induced by renal ischemia is presumably mediated via GABA(B) receptor stimulation in the central nervous system rather than peripheral GABA(B) receptor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1521-0103
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
338
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
767-74
pubmed:meshHeading
pubmed-meshheading:21632868-Acute Kidney Injury, pubmed-meshheading:21632868-Animals, pubmed-meshheading:21632868-Baclofen, pubmed-meshheading:21632868-Benzylamines, pubmed-meshheading:21632868-Bicuculline, pubmed-meshheading:21632868-Blood Urea Nitrogen, pubmed-meshheading:21632868-GABA Agonists, pubmed-meshheading:21632868-GABA Antagonists, pubmed-meshheading:21632868-Injections, Intravenous, pubmed-meshheading:21632868-Injections, Intraventricular, pubmed-meshheading:21632868-Kidney, pubmed-meshheading:21632868-Kidney Function Tests, pubmed-meshheading:21632868-Male, pubmed-meshheading:21632868-Phosphinic Acids, pubmed-meshheading:21632868-Rats, pubmed-meshheading:21632868-Rats, Sprague-Dawley, pubmed-meshheading:21632868-Receptors, GABA-A, pubmed-meshheading:21632868-Receptors, GABA-B, pubmed-meshheading:21632868-Reperfusion Injury, pubmed-meshheading:21632868-Sympathetic Nervous System, pubmed-meshheading:21632868-gamma-Aminobutyric Acid
pubmed:year
2011
pubmed:articleTitle
Mechanisms underlying the renoprotective effect of GABA against ischemia/reperfusion-induced renal injury in rats.
pubmed:affiliation
Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan. kobuchi-s@huhs.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't