Linked Life Data

2162883

Source:http://linkedlifedata.com/resource/pubmed/id/2162883

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-7-27
pubmed:abstractText
Increased calcium uptake in vascular tissues, leading to elevated cytosolic free calcium, has been implicated in the pathophysiology of hypertension. In this study we investigated the in vitro effect of deuterium oxide (D2O) on calcium uptake in Sprague-Dawley (SD) rat aortae as well as the effects of 25% D2O, orally administered to spontaneously hypertensive and Wistar-Kyoto (WKY) rats, on systolic blood pressure and aortic calcium uptake. The high calcium uptake induced by phenylephrine (50 mumols/l) via receptor-operated channels and by KCl (80 mmol/l) via voltage-operated channels in SD rat aortae was effectively reduced by D2O in a concentration-dependent manner. These results suggest that D2O, acting like a calcium channel blocker, effectively normalized vascular calcium uptake mechanisms. When, at 7 weeks of age, spontaneously hypertensive rats were given 25% D2O in their drinking water for a period of 6 weeks, the development of high systolic blood pressures and the associated increases in aortic calcium uptake were effectively prevented. D2O treatment did not affect blood pressures in normotensive WKY rats. The parallel increases in systolic blood pressure and in vascular calcium uptake suggest that increased calcium uptake mechanisms are associated with hypertension. Furthermore, D2O appears to prevent hypertension by normalizing calcium uptake in vascular smooth muscle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0263-6352
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of deuterium oxide (D2O) on the development of hypertension and Ca2+ homeostasis in spontaneously hypertensive rats.
pubmed:affiliation
Department of Medicine, Memorial University of Newfoundland, St. John's, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't