Linked Life Data

21628129

Source:http://linkedlifedata.com/resource/pubmed/id/21628129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-6-1
pubmed:abstractText
The skin is equipped with nerve fibers subserving the senses for touch, temperature, pain and itch. Thickly myelinated A?-fibers are linked to low threshold mechano-receptors responsible to detect vibration and slight indentation of the skin. Among the thinly myelinated A?-fibers one class is crucial for the cold detection, but there also nociceptive A?-fibers for the detection fast rising noxious heat and punctate mechanical stimuli. Unmyelinated C-fibers consist of various classes mediating nociceptive (pain and itch) and non-nociceptive (warmth, pleasant touch) sensations. The unmyelinated C-fibers have close contact to the keratinocytes and the interaction between C-fibers and local skin cells is of particular interest, as efferent neuronal function has both local trophic and immunomodulatory function. In turn, excitability of C-fibers is governed in part by neurotrophins from neighbouring skin cells such as keratinocytes. This mechanism is held responsible to induce and maintain chronic itch and pain conditions. Beyond this interaction recently a direct involvement of keratinocytes in the transduction process has been discussed especially for temperature and noxious stimuli, as keratinocytes express a variety of sensory transduction molecules. Thus, the interplay between neurons and non-neuronal cells is operational not only in basic physiology, but also in chronic itch and pain patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1167-1122
pubmed:author
pubmed:issnType
Print
pubmed:volume
21 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Neuronal sensitivity of the skin.
pubmed:affiliation
Department of Anesthesiology Mannheim, University Heidelberg, Mannheim. martin.schmelz@medma.uniheidelberg.de
pubmed:publicationType
Journal Article, Review