Linked Life Data

21627081

Source:http://linkedlifedata.com/resource/pubmed/id/21627081

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-6-28
pubmed:abstractText
Biointerfaces capable of biological recognition and specificity are sought after for conferring bioinspired functionality onto synthetic biomaterials systems. This is important for biosensing, bioseparations, and biomedical materials. Here, we demonstrate how intrinsic polymer-protein interactions between highly localized polyethylene glycol (PEG) brushes and PEG-binding antibodies can be used for sorting specific biomolecules from complex bulk biological fluids to synthetic nanoscale targets. A principal feature lies with the antifouling property of PEG that prevents unspecific binding. Exclusive access is provided by anti-PEG, which acts as a biohybrid molecular adaptor that sifts out and targets specific IgG "cargo" from solution to the PEG. The PEG can be reversibly washed and targeted in blood serum, which suggests potential benefits in technological applications. Moreover, anti-PEG binding triggers a stimuli-responsive conformational collapse in the PEG brush, thereby imparting an intrinsic "smart" biorecognition functionality to the PEG that can considerably impact its use as an antifouling biomaterial.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1936-086X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5180-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Synthetic protein targeting by the intrinsic biorecognition functionality of poly(ethylene glycol) using PEG antibodies as biohybrid molecular adaptors.
pubmed:affiliation
Biozentrum and the Swiss Nanoscience Institute, University of Basel, Klingelbergstrasse 70, Basel 4056, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't