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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2011-8-9
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pubmed:abstractText |
New Delhi metallo-?-lactamase-1 (NDM-1) is a recently identified metallo-?-lactamase that confers resistance to carbapenems and all other ?-lactam antibiotics, with the exception of aztreonam. NDM-1 is also associated with resistance to many other classes of antibiotics. The enzyme was first identified in organisms isolated from a patient in Sweden who had previously received medical treatment in India, but it is now recognized as endemic throughout India and Pakistan and has spread worldwide. The gene encoding NDM-1 has been found predominantly in Escherichia coli and Klebsiella pneumoniae. We describe the isolation NDM-1-producing organisms from two patients in Toronto, Ontario. To the best of our knowledge, this is the first report of an organism producing NDM-1 that was locally acquired in Canada. We also discuss the evidence that NDM-1 can affect bacterial species other than E. coli and K. pneumoniae, the limited options for treatment and the difficulty laboratories face in detecting organisms that produce NDM-1.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-15714408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-19770275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-1977766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-20085604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-20577157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-20705517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-21136256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-21189345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-21192866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-21220461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-21291595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-21291614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-21325558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-21430097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21624908-21788418
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1488-2329
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pubmed:author |
pubmed-author:BayleyMarkM,
pubmed-author:BoydDavid ADA,
pubmed-author:CarrLesleyL,
pubmed-author:DedierHelenH,
pubmed-author:EdwardsIris-AnnIA,
pubmed-author:JinnahFatemaF,
pubmed-author:KusJulianne VJV,
pubmed-author:LarocqueCindyC,
pubmed-author:LouieLisaL,
pubmed-author:LowDonald EDE,
pubmed-author:McGeerAllison JAJ,
pubmed-author:MelanoRobertoR,
pubmed-author:MulveyMichael RMR,
pubmed-author:OkeahialamChristopherC,
pubmed-author:PikeKarenK,
pubmed-author:PoutanenSusan MSM,
pubmed-author:RichardsonDenyseD,
pubmed-author:SimorAndrewA,
pubmed-author:TadrosManalM,
pubmed-author:WhiteheadCynthiaC,
pubmed-author:WilleyBarbara MBM
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1257-61
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pubmed:meshHeading |
pubmed-meshheading:21624908-Aged,
pubmed-meshheading:21624908-Aged, 80 and over,
pubmed-meshheading:21624908-Female,
pubmed-meshheading:21624908-Humans,
pubmed-meshheading:21624908-Male,
pubmed-meshheading:21624908-Morganella morganii,
pubmed-meshheading:21624908-Ontario,
pubmed-meshheading:21624908-Polymerase Chain Reaction,
pubmed-meshheading:21624908-Proteus mirabilis,
pubmed-meshheading:21624908-Urine,
pubmed-meshheading:21624908-beta-Lactam Resistance,
pubmed-meshheading:21624908-beta-Lactamases
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pubmed:year |
2011
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pubmed:articleTitle |
New Delhi metallo-?-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection.
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pubmed:affiliation |
University Health Network and Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex Department of Microbiology, Toronto, Canada.
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pubmed:publicationType |
Journal Article,
Case Reports
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