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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-8-17
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pubmed:abstractText |
The electrically remodeled canine heart after chronic AV block (CAVB) has a high susceptibility for drug-induced torsade de pointes (TdP) arrhythmias. Although focal mechanisms have been considered for initiation, there is still controversy about whether reentry is the dominant mechanism for perpetuation of TdP. In this animal model with known nonuniform prolongation of repolarization, the mechanism of perpetuation of TdP arrhythmia was explored.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1941-3084
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pubmed:author |
pubmed-author:AntoonsGudrunG,
pubmed-author:BeekmanJet DJD,
pubmed-author:BoulaksilMohamedM,
pubmed-author:HoutmanMarien J CMJ,
pubmed-author:JungschlegerJerome GJG,
pubmed-author:MaessenJos GJG,
pubmed-author:VosMarc AMA,
pubmed-author:WildersRonaldR,
pubmed-author:de BakkerJacques M TJM,
pubmed-author:de BoerTeun PTP,
pubmed-author:van RijenHarold V MHV,
pubmed-author:van VeenToon A BTA,
pubmed-author:van der HeydenMarcel A GMA,
pubmed-author:van der HulstFerenc FFF
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
566-76
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pubmed:meshHeading |
pubmed-meshheading:21622813-Animals,
pubmed-meshheading:21622813-Anti-Arrhythmia Agents,
pubmed-meshheading:21622813-Atrioventricular Block,
pubmed-meshheading:21622813-Collagen,
pubmed-meshheading:21622813-Connexin 43,
pubmed-meshheading:21622813-Disease Models, Animal,
pubmed-meshheading:21622813-Dogs,
pubmed-meshheading:21622813-Electrophysiologic Techniques, Cardiac,
pubmed-meshheading:21622813-Heart Ventricles,
pubmed-meshheading:21622813-Hypertrophy,
pubmed-meshheading:21622813-Refractory Period, Electrophysiological,
pubmed-meshheading:21622813-Sodium Channels,
pubmed-meshheading:21622813-Sulfonamides,
pubmed-meshheading:21622813-Torsades de Pointes,
pubmed-meshheading:21622813-Ventricular Dysfunction, Left,
pubmed-meshheading:21622813-Ventricular Dysfunction, Right
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pubmed:year |
2011
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pubmed:articleTitle |
Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
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pubmed:affiliation |
Department of Medical Physiology and Department of Cardio-Thoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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