Linked Life Data

21622649

Source:http://linkedlifedata.com/resource/pubmed/id/21622649

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-8-12
pubmed:abstractText
To lend clarity to inconsistent prior findings of an inverse association between ultraviolet radiation (UVR) exposure and risk of lymphoid malignancies, we examined the association of prospectively ascertained residential ambient UVR exposure with risk of non-Hodgkin lymphomas (NHLs), multiple myeloma (MM), and classical Hodgkin lymphoma in the California Teachers Study cohort. Among 121 216 eligible women, 629 were diagnosed with NHL, 119 with MM, and 38 with Hodgkin lymphoma between 1995-1996 and 2007. Cox proportional hazards regression was used to estimate incidence rate ratios (RRs) with 95% confidence intervals (CIs). Residential UVR levels within a 20-km radius were associated with reduced risk of overall NHL (RR for highest vs lowest statewide quartile of minimum UVR [? 5100 vs < 4915 W-h/m(2)], 0.58; 95% CI, 0.42-0.80), especially diffuse large B-cell lymphoma (RR, 0.36; 95% CI, 0.17-0.78) and chronic lymphocytic leukemia/small lymphocytic lymphoma (RR, 0.46; 95% CI, 0.21-1.01), and MM (RR for maximum UVR, 0.57; 95% CI, 0.36-0.90). These associations were not modified by skin sensitivity to sunlight, race/ethnicity, body mass index, or neighborhood socioeconomic status. Dietary vitamin D also was not associated with risk of lymphoid malignancies. These results support a protective effect of routine residential UVR exposure against lymphomagenesis through mechanisms possibly independent of vitamin D.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
11
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1591-9
pubmed:meshHeading
pubmed-meshheading:21622649-Adult, pubmed-meshheading:21622649-Aged, pubmed-meshheading:21622649-Aged, 80 and over, pubmed-meshheading:21622649-Bone Density Conservation Agents, pubmed-meshheading:21622649-California, pubmed-meshheading:21622649-Dietary Supplements, pubmed-meshheading:21622649-Faculty, pubmed-meshheading:21622649-Female, pubmed-meshheading:21622649-Hodgkin Disease, pubmed-meshheading:21622649-Humans, pubmed-meshheading:21622649-Leukemia, Lymphocytic, Chronic, B-Cell, pubmed-meshheading:21622649-Lymphoma, Large B-Cell, Diffuse, pubmed-meshheading:21622649-Lymphoma, Non-Hodgkin, pubmed-meshheading:21622649-Middle Aged, pubmed-meshheading:21622649-Multiple Myeloma, pubmed-meshheading:21622649-Proportional Hazards Models, pubmed-meshheading:21622649-Prospective Studies, pubmed-meshheading:21622649-Questionnaires, pubmed-meshheading:21622649-Risk Assessment, pubmed-meshheading:21622649-Risk Factors, pubmed-meshheading:21622649-Sunlight, pubmed-meshheading:21622649-Ultraviolet Rays, pubmed-meshheading:21622649-Vitamin D, pubmed-meshheading:21622649-Young Adult
pubmed:year
2011
pubmed:articleTitle
Adulthood residential ultraviolet radiation, sun sensitivity, dietary vitamin D, and risk of lymphoid malignancies in the California Teachers Study.
pubmed:affiliation
Cancer Prevention Institute of California, Fremont, CA, USA. ellen@cpic.org
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural