Source:http://linkedlifedata.com/resource/pubmed/id/21622133
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2011-5-30
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pubmed:abstractText |
MicroRNA-210 (miR-210), a master and pleiotropic hypoxia-microRNA, plays multiple roles in brain ischemia. However, miR-210 expression and its function in humans have not been explored. The aim of our study is to evaluate the correlation of blood miR-210 with clinical findings in acute ischemic stroke. Blood samples were obtained from stroke patients (n=112) and healthy controls (n= 60). MiR-210 was measured at within 3, 7 and 14 days after stroke using a quantitative PCR technique. Stroke severity and clinical outcome were evaluated by NIHSS and modified Rankin Score. Both blood and brain miR-210 in ischemic mice was examined and the correlation was investigated. Compared to healthy controls, blood miRNA-210 was significantly decreased in stroke patients (0.93 vs. 1.36; P=0.001), especially at 7 days (0.56 vs. 1.36; P=0.001) and 14 days of stroke onset (0.50 vs. 1.36; P=0.001). The cut off point of miR-210 in diagnosis was 0.505 with 88.3 per cent sensitivity. MiR-210 level in stroke patients with good outcome was significantly higher than patients with poor outcome (1.2 vs. 0.44; P=0.012). The correlation between blood and brain miR-210 in ischemic mice was positive (R2=0.57, P=0.001). Blood miR-210 is a novel sensitive biomarker for clinical diagnosis and prognosis in acute cerebral ischemia.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1945-0508
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1265-72
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pubmed:meshHeading |
pubmed-meshheading:21622133-Acute Disease,
pubmed-meshheading:21622133-Aged,
pubmed-meshheading:21622133-Animals,
pubmed-meshheading:21622133-Biological Markers,
pubmed-meshheading:21622133-Brain Ischemia,
pubmed-meshheading:21622133-Disease Models, Animal,
pubmed-meshheading:21622133-Female,
pubmed-meshheading:21622133-Humans,
pubmed-meshheading:21622133-Male,
pubmed-meshheading:21622133-Mice,
pubmed-meshheading:21622133-Mice, Inbred ICR,
pubmed-meshheading:21622133-MicroRNAs,
pubmed-meshheading:21622133-Middle Aged,
pubmed-meshheading:21622133-Polymerase Chain Reaction
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pubmed:year |
2011
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pubmed:articleTitle |
MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia.
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pubmed:affiliation |
Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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