Linked Life Data

21622111

Source:http://linkedlifedata.com/resource/pubmed/id/21622111

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-5-30
pubmed:abstractText
Although recent studies have shown that female germ cells can be produced from stem-cell lines in mice, whether these germ cells can interact with ovarian somatic cells (OSCs) to form primordial follicles (PFs) is still unclear. Here, we found after the PF pool is established, Irx3 and FoxL2 which were extensively expressed in the OSCs of the perinatal mouse decreased. Additionally, during primordial folliculogenesis, down-regulation of FoxL2 prevents OSCs invading germ cell cysts. Therefore, we investigated whether OSCs at different stages of folliculogenesis were able to reconstitute PFs with fetal ovarian germ cells in vitro. In this system, neither OSCs at the post-PF pool-establishment stage nor OSCs from normal or doxorubicin-treated adult mice were able to reconstitute PFs. Mice eliminated most of pre-existing PFs failed to exhibit any spontaneous regeneration of PFs. Our results suggest that OSCs can only support physiological primordial folliculogenesis during the prenatal period. OSCs lose the ability to form PFs after the establishment of the PF pool may be another reason why the PF pool is non-renewable in most adult mammals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1945-0508
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1025-33
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Stage-specific mice ovarian somatic cell is involved in primordial folliculogenesis.
pubmed:affiliation
State Key Laboratory for Agro-biotechnology, College of Biological Sciences, China Agricultural University, Beijing, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't