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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-5-30
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pubmed:abstractText |
Preformed donor-specific human leukocyte antigen (HLA) antibodies have been associated with allograft dysfunction and failure. However, recipients of HLA-identical kidneys can develop acute humoral rejection, implicating putative pathogenic antibodies that are directed against non-HLA antigens. We investigated the presence of endothelial cell-reactive antibodies in 11 patients who experienced early loss of their transplanted kidneys owing to humoral rejection and 1 loss from renal venal thrombosis. We examined the potential efficacy of intravenous immunoglobulin to block the binding of these antibodies, as previously suggested for anti-HLA antibodies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1873-2623
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pubmed:author |
pubmed-author:BorbaS C PSC,
pubmed-author:CastroM C RMC,
pubmed-author:David DaisaS RSR,
pubmed-author:David-NetoEE,
pubmed-author:FerreiraS C PSC,
pubmed-author:GlotzDD,
pubmed-author:IanhezL ELE,
pubmed-author:KalinHH,
pubmed-author:NahasWW,
pubmed-author:PanajotopoulosNN,
pubmed-author:RodriguesHH,
pubmed-author:RondaCC,
pubmed-author:ViggianiC SCS
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pubmed:copyrightInfo |
Copyright © 2011. Published by Elsevier Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1345-8
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pubmed:meshHeading |
pubmed-meshheading:21620126-Antibodies,
pubmed-meshheading:21620126-Brazil,
pubmed-meshheading:21620126-Cell Line,
pubmed-meshheading:21620126-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:21620126-Endothelial Cells,
pubmed-meshheading:21620126-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21620126-Flow Cytometry,
pubmed-meshheading:21620126-Graft Rejection,
pubmed-meshheading:21620126-Histocompatibility Antigens Class I,
pubmed-meshheading:21620126-Histocompatibility Testing,
pubmed-meshheading:21620126-Humans,
pubmed-meshheading:21620126-Immunity, Humoral,
pubmed-meshheading:21620126-Immunoglobulins, Intravenous,
pubmed-meshheading:21620126-Kidney Transplantation,
pubmed-meshheading:21620126-Transplantation, Homologous,
pubmed-meshheading:21620126-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
Non-human leukocyte antigen antibodies reactive with endothelial cells could be involved in early loss of renal allografts.
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pubmed:affiliation |
Laboratory of Immunology, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil. cronda51@hotmail.com
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pubmed:publicationType |
Journal Article
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