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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1990-7-13
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pubmed:abstractText |
To determine whether c-fos is involved in avian leukosis virus-induced nephroblastoma, 28 tumors from chickens were analyzed for novel fos fragments. DNA from 1 of 16 clonal outgrowths (in chicken 6561) contained novel fos-related EcoRI and KpnI fragments which hybridized to both v-fos and viral probes. Oncogenicity tests using filtered 6561 tumor cell homogenates did not reveal a tumor-inducing transduction of c-fos. We conclude that c-fos is only an occasional target for proviral insertions or new transductions in avian leukosis virus-induced nephroblastoma. The results also identify a polymorphism in c-fos in K28 chickens and demonstrate that unintegrated viral DNA is not a general characteristic of avian leukosis virus-induced nephroblastoma.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-14494905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-177194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-2538646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-2579505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-2824811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-2831403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-2841495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-2897475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-2985798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-2986110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-2989556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-3001351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-3005614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-3011401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-3029416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-4308011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-6252351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-6261142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-6267589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-6276760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-6284974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-6302361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161956-6305505
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3541-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2161956-Animals,
pubmed-meshheading:2161956-Avian leukosis virus,
pubmed-meshheading:2161956-Blotting, Southern,
pubmed-meshheading:2161956-Chickens,
pubmed-meshheading:2161956-DNA Probes,
pubmed-meshheading:2161956-Kidney Neoplasms,
pubmed-meshheading:2161956-Oncogenes,
pubmed-meshheading:2161956-Proto-Oncogene Proteins,
pubmed-meshheading:2161956-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:2161956-Restriction Mapping,
pubmed-meshheading:2161956-Wilms Tumor
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pubmed:year |
1990
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pubmed:articleTitle |
Infrequent involvement of c-fos in avian leukosis virus-induced nephroblastoma.
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pubmed:affiliation |
Department of Pathology, University of Massachusetts Medical Center, Worcester 01655.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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