Linked Life Data

21618875

Source:http://linkedlifedata.com/resource/pubmed/id/21618875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-5-30
pubmed:abstractText
The eukaryotic exosome complex is built around the backbone of a 9-subunit ring similar to phosporolytic ribonucleases such as RNase PH and polynucleotide phosphorylase (PNPase). Unlike those enzymes, the ring is devoid of any detectable catalytic activities, with the possible exception of the plant version of the complex. Instead, the essential RNA decay capability is supplied by associated hydrolytic ribonucleases belonging to the Dis3 and Rrp6 families. Dis3 proteins are endowed with two different activities: the long known processive 3'-5' exonucleolytic one and the recently discovered endonucleolytic one. Rrp6 proteins are distributive exonucleases. This chapter will review the current knowledge about the catalytic properties of theses nucleases and their interplay within the exosome holocomplex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
702
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-78
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Catalytic properties of the eukaryotic exosome.
pubmed:affiliation
Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
pubmed:publicationType
Journal Article, Review